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Some Very Important Things to Understand Regarding CBD Dosage

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We’ve covered several aspects of CBD here on CBDmyth. Among the things left to discuss are CBD dosage. How much CBD is too much? How much is safe to consume? In this article, we’ll answer these questions.

CBD dosage and solution

 CBD dosage and the solution type are interdependent. For consumer convenience, CBD is available in several forms. One solution type is different from another. CBD tincture and edible oil are completely different. If you are taking tincture, a little dosage is enough. It’s the reason consumers use dropper for tincture.

CBD edible oil comes with physician recommended dosage. We’ll discuss that in a moment. First, let us understand how CBD topicals and salves work. The context of dosage is irrelevant when you are using these as topical ointments are typically rubbed over the skin. Even if use extra amount, there won’t be any harm.

Concentration in solution

CBD concentration varies depending on the solution type. Every CBD solution comes with a specific amount of concentration. There are concentrations that have below 10 MG CBD in them. Alongside these solutions, exist other solutions containing over 100 MG CBD.

You might feel tempted to know how the dosage is decided. It’s decided on the basis of what kind of illness the CBD drug is supposed to treat.

Illness and CBD dosage

 As we’ve discussed in the articles that we posted earlier on this site, CBD treats a rainbow collection of illnesses. From epilepsy to cancer, from chronic pain to digestive problems, from fibromyalgia to memory-loss, CBD treats almost all diseases.

The dosage varies. Below you’ll find some of the illnesses and the corresponding dosage:

  • Cancer: The claim that CBD can beat cancer got validation after Tommy Chong recovered from it. An average person needs 60ml of daily dosage for 3 months. That said, the dosage depends on factors like age, stage of cancer and the consumer’s immune system.
  • Chronic pain: Most people who consume CBD do that to alleviate pain. The recommended dosage is 5 ml to 25 ml a day for a little more than 3 weeks. The dosage may vary depending on the severity of the pain.
  • Nerve problems: Dosage depends on specific problems, not on broad-range problems. Severe form of schizophrenia requires 50-1200 mg CBD everyday. MS patients, on the other hand, requires a mix of THC and CBD for 15 long weeks, up to 120 mg a day.
  • Sleep problems: People suffering from insomnia are recommended to take 50-150 mg of CBD by mouth.

It’s always wise to consult an expert than to decide how much you’ll take all by yourself.

Global CBD standard

 Now let’s come to the core issue. What is the global CBD serving standard? Or does any such standard exist in the first place?

Currently, there’s no such standard as pharma companies haven’t fully embraced CBD. However, there’s a strong need of a uniform standard?

Why so?

Because CBD brands often confuse people by suggesting different dosage for the same illness. If there’s an internationally approved standard, consumers won’t be confused. CBDoilReviw.org recommends a dosage of 25 mg a day for a month or until the symptoms are relieved. However, this recommendation is unanimously endorsed.

Any side-effect?

 Things may not always go as they are planned. CBD consumption is safe. However, the possibility of side-effects cannot be completely ruled out, more so because we don’t fully know how CBD works. Common side-effects of CBD include drowsiness, lightheadedness, etc. Fortunately, these side-effects are easy to deal with.

Consumption method and dosage

 Does the method of consumption make any difference in how much CBD would be needed? Yes, it does. We’ve discussed the most popular consumption techniques earlier. When you are smoking or vaping, you are puffing in a lot of smoke and hold it down there. That means, a decent amount of CBD entering into your body. However, if you use a mouth spray or use a dropper and hold CBD under your tongue, the dosage amount wouldn’t be high.

When CBD is used in the form of tincture, the dosage required is so low that it is called micro dosage. When someone uses a vape pen to consume CBD, the consumption limit normally doesn’t cross 40 mg.

FDA on dosage

 What’s interesting to note here is FDA doesn’t even consider CBD as a legit drug, but as a food supplement. That’s kind of odd considering the medical community appreciating CBD. FDA doesn’t recommend any dosage. They instruct consumers to check the serving on the product’s label.

Customers should follow a safe dosage, which is 5-30 mg a day and see whether their problem persists. If it does, consult with experts.

In summary

 It’s old news that CBD cures diseases. Even the most difficult to treat to health conditions can be treated by CBD. All that patients need to do is find the right dosage, based on their health, severity of the disease and the method of consumption.

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A Detailed Look at CBD’s Effectiveness in Treating Neurological Disorders

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In the present article, we’ll discuss CBD’s effectiveness in treating neurological disorders. Medical practitioners from various parts of the world are now using cannabis extract to cure neurological problems and resulting pain and inflammation. And so far, there have been many success stories.

Nature of studies conducted

 Before we start our discussion, here’s a synopsis of the studies conducted and the takeaways gleaned from them, presented in bulleted points below:

  • The studies were conducted by groups of health professionals. Some were privately sponsored, some were groups of esteemed neurologists and some were affiliated by the government.
  • A plethora of disorders, all treated by CBD were studied, including seizures, huntington disease, cervical dystonia, multiple sclerosis, parkinson disease, tourette syndrome, epilepsy.
  • Both medically approved and non-medical marijuana consumption methods were reviewed. Pills like oral cannabis extract (ORE), Nabiximols, etc were studied alongside smoking or vaping cannabis.

The evidence from these studies revealed both THC and CBD are effective in the treatment of neurological diseases, though in varying degrees.

Findings, in a nutshell

 The findings were quite interesting. From the studies, it appears the scarier the disease, the better the relief. For example, multiple sclerosis (MS) patients uniformly complain about pain, which sometimes become excruciating. Oral CBD extracts have been found to alley the pain, arising from MS.

Synthetic THC has been reported to reduce the symptoms of spasticity, especially the pain that people unfortunate enough to have to deal with this disease bear. The study shows a short-term use of CBD and THC and a mixture of them can alleviate pain whereas for complete cure, long-term use is preferred.

The science behind it

 Research on medical cannabis has made significant strides lately. The previous consensus was CBD directly binds to a group of endocannabinoid receptors. But recent studies found that CBD interacts with the endocannabinoid system only in vitro at supraphysiological concentrations. This has prompted scientists to understand its molecular targets better. They believe the answer to how CBD cures neurological disorders lies in its molecules.

The molecular targets that have so far been identified encompass a number of ion channels, transporters, enzymes and receptors. The most interesting about these studies is the wayward behavior of the targets.

Because of volatile behavior of CBD’s molecular targets, it’s difficult for scientists to determine whether CBD usage and recovery from neurological problems are linked or simply correlated. Luckily for them, some targets were totally consistent with the results of previous clinically controlled neurological treatment.

 It’s safe to assume that there’s a causative relation between CBD’s molecular targets and recovery from neurological disorders. With the progress of ongoing scientific research, this relation will be explored.

The brain benefits

 The brain is probably the most important area of the central nervous system. CBD’s impact on brain and the consequences are all well-documented. The way CBD acts upon the brain speeds up the recovery from neurological problems.

Here’s how it happens:

CBD acts upon the 5-HT1A receptor. This receptor is known as the serotonin receptor. It’s one of very few receptors which CBD actively stimulates. According to studies, some serotonin receptor agonists and antagonists provide neuroprotection. One such agonist is flibanserin. CBD releases cannabinoid receptor agonists, which work as proxies for serotonin drugs.

CBD also activates the opioid receptor. The benefits? Pain and nonstop inflammation are both significantly reduced. Neurological diseases, especially the ones involving the spine are accompanied by pain.

What the law says

 Cannabis is undoubtedly effective against neurological problems. But don’t get excited already. Not all states permit you to consume it. There are 21 states other than Washington DC where the consumption of medical marijuana is allowed.

If you are thinking you can buy medical marijuana from the nearest drughouse because you live in one of the 21 states, you are wrong. In the United States, medical marijuana is FDA controlled. FDA approved medical marijuana drugs are dronabinol and nabilone.

Fortunately, some pill is not FDA approved only means a licensed health practitioner will not prescribe you that medicine. You can still get it. Some states approve the sale of cannabis products that are high in CBD and low in THC. You can buy these products. They are unlikely to be available in drugstores. So buy online.

Caution about side-effects

 Cannabis users, especially those who want to recover from neurological diseases must be cautious. Clinical trials reveal cannabis usage come with a number of side-effects, including dizziness, nausea and vomiting. These side-effects may prove fatal for anyone suffering from nerve disorders.

CBD products is far safer in this regard. That’s chiefly because they have an optimal ratio of CBD and THC, making it safe to use and highly effective.

Summing up

 The anecdotal and clinical evidence all confirm that CBD is useful for neurological patients. Contemporary scientific research echo this sentiment but has so far been unable to pin on all the factors, responsible for treating neuro problems. Hopefully, future research will shed enough light on it.

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What Makes CBD an Efficient Pain Reliever?

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On CBDMyth, we’ve been receiving a relatively high volume of emails lately. Every one in five emails is a request from someone asking whether CBD can reduce pain completely.

After reading all these emails, I’ve decided to churn out a new article – one that pivots around how CBD relieves pain, the science behind it, and what consumers should realistically expect from this magic herb oil.

Reason behind body pain

 Pain in the body is not a disease in itself, it’s rather a symptom indicating something is wrong with your health. The parts of the body most susceptible to pain are muscles and bones. You can have pain in glands and veins too, but it’s a bit unusual as most people suffer from either muscle or joint pain.

How CBD treats pain

 Marijuana, even addictive, is used in medical field. There have been anecdotal as well as scientific evidence confirming CBD’s usefulness in the treatment of pain. What makes CBD an efficient pain-reliever? CBD is a compound that binds with a specific group of endocannabinoid receptors. The receptors are triggered to release neurotransmitters that numb the body’s natural capacity to receive pain.

Research has shown most pains are neuropathic in nature and tampering with the nerve pathways can block or minimize the sensation of pain.

Is CBD like analgesic?

 Analgesia is not intrinsic to CBD, but it shares borders with analgesic drugs. Randomized clinical trials conducted under the supervision of medical teams found CBD’s mechanism mimics that of analgesic. The difference is analgesic drugs don’t stimulate the CB1 and CB2 receptors, something that’s typically done by CBD and other compounds found in cannabis.

Observing CBD’s unique pain relieving characteristics, scientists assigned a name to the underlying mechanism. The name is cannabinoid analgesia. It’s a term that refers to cannabinoid induced analgesia.

The science, in nutshell

 The most well-researched cannabinoid type is called 21-carbon terpenophenolic. It’s a naturally occurring cannabinoid type and phytocannabinoids genus of cannabis plant is its source. All its compounds are nalgesic, but not equally good at that. Tetrahydrocannabinol or THC is the strongest. One the flipside, it makes people high.

THC is a major phytocannabinoid. Its activities are supplemented and to some extent, kept in check by other phytocannabinoids like CBD, Flavonoids and Terpenoids. Scientists have synthesized these cannabinoids in clinical trials. The end result is CBD products, low in THC and high in CBD, retaining THC’s analgesic qualities sans the intoxicating effect.

Effect on cannabinoid receptor

 Mammalian brains possess a minimum of two cannabinoid receptors. These are called CB1 and CB2 receptors. CB1 receptors involve neurons in the central and peripheral nervous system. CB2 receptors are made of non-neuronal tissues in these regions.

CBD binds to CB1 receptors via allosteric enzyme. But it binds directly to CB2 receptors. This way, cannabinoid induced antinociception is produced. Antinociception plays an important role in pain reduction – the kind of pain that affects not only humans but all animals. According to research, if chronic pain is caused by nerve damage or anti-inflammatory drugs, antinociception can suppress it pretty quickly.

Cannabinoid receptors in the central and peripheral pathways are distributed. Scientists are now studying these receptors to understand how cannabinoid engenders antinociception. Hopefully, their research will shed new light onto CBD’s effectiveness in treating hard-to-treat pain.

Alternative to painkillers

 CBD products – be them edible oil or salve – can be a great alternative to NSAID drugs or painkillers. Both are harmful to the body. Doctors sometimes dismiss these drugs calling them unfit for human consumption.

Another reason CBD is a viable alternative to OTC painkillers is it gradually eliminates pain completely. Painkillers, even though work quickly, don’t treat the root cause of the pain. As a result, the pain comes back when the effect of the drug is over.

Is pain really physical?

 Insights obtained from research into CBD leads to an important question. Is pain completely physical or partly psychological? Oftentimes, the physiological factors leading to pain disappear but the pain still remains.

How’s that possible? One credible explanation is the neural pathways responsible for pain might continue to send signal even after an injury or a wound heals. This way, people continue to suffer from pain.

When CBD works on the endocannabinoid receptors, it eliminates the neuropathological factors contributing to pain. This is how, CBD cures physiological as well as psychological factors associating to pain.

An endocannabinoid modulator

 THC and CBD share a number of neuroprotective characteristics. CBD however, is an endocannabinoid modulator unlike THC as the latter doesn’t bind to vanilloid receptors. CBD being a TRPV1 agonist, inhibits a number of enzymes including fatty acid amidohydrolase and hydrolytic enzyme.

Summary

 It’s clear from the discussion above that CBD is way different from painkillers available in the market. Not only it doesn’t have any harmful effect, but it actively restores the body’s normal functioning so that it heals the wound/injury itself and get rid of the pain once and forever. So, next time your back or shoulder aches, do give CBD a chance.

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What is CBD, How it Works and Why is it So Popular?

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What is CBD

Medical marijuana is a hotly debated issue right now. There are arguments for and against. Marijuana contains several compounds. One of these compounds is Cannabidiol or CBD. It has lately caught the attention of the medical community. The community has reached a consensus that CBD has therapeutic benefits.

Alongside ordinary users who propped this consensus were celebrities known for their CBD consumption habit. They all held that CBD gave them relief from pain and inflammation. If you want to know who these people are, here’s a list.

Cannabis and CBD

Typical bong rippers smoke cannabis only to get high – not because they want to accomplish some productive goals in life. These people are looked down upon. And so is cannabis. But the abhorrence felt towards cannabis is completely unreasonable. Cannabis is beneficial for us, people give it a bad name by abusing it, instead of using.

This needs to change and CBD is changing it. According to recent studies, Tetrahydrocannabinol or THC causes the mind-altering effect that stoners are so fond of. But beyond that, THC has little medical value. CBD, on the other hand, can sort out a wide range of ailments.

We are going to discuss what these ailments are and how CBD functions as a bulwark against them. But first,

What is CBD?

CBD is medically defined as a non-psychoactive marijuana compound. It is found in marijuana as well as in hemp. The two strains of CBD – hemp-derived and cannabis-derived – differ from each other. Even though CBD accounts for up to 40% of cannabis extract, it is not as widely distributed as THC.

CBD’s chemical structure has 21 molecules of carbon, 30 molecules of hydrogen and 2 molecules of oxygen. Its molar mass is 314.464 grams per mole.

How does CBD work?

Human brain is dense with cannabinoid receptors. Aside from the brain, these receptors exist in the immune system.

Cannabinoid receptors fall into two categories – CB1 and CB2 receptors. The first types of receptors are found in the brain and the second types in the immune system.

CBD, unlike other cannabinoids, doesn’t actively stimulate CB1 and CB2 receptors. Instead, it activates the following receptors:

  • 5-hydroxytryptamine 1a receptors: Also known as serotonin receptor, 5-hydroxytryptamine 1a receptor or 5HT1a receptor is a subtype of 5HT receptor. Serotonin is a neurotransmitter. Its imbalance can cause anxiety and mood swing. CBD stimulates 5HT1a receptor to fix the imbalance and bring a calming feeling.
  • GPR55 receptors: GPR55 is found in an area in the brain called cerebellum. These receptors accelerate osteoclast cell function, which ripens into osteoporosis – a disease that weakens the bones and makes them too fragile.
  • Nuclear receptors: Each cell has nucleus containing PPRA receptors. These are called nuclear receptors. When these receptors are activated, tumor inhibiting triggers are activated. Aside from that, amyloid-beta plaque starts to reduce. By activating nuclear receptors, CBD fights with cancer and Alzheimer’s disease.

CBD works on the molecular level. Scientists have studied and confirmed it but till date it’s not clear to them how. They are still trying to explore CBD and hopefully, an explanation of how CBD’s healing effect impacts the molecules, will be offered soon.

Benefits of CBD

As mentioned earlier, CBD can heal a wide range of health issues, including pain, inflammation, tumor, diabetes, seizure, nausea, neurological impairment, oxidative injury, digestive problems, epilepsy, anxiety, schizophrenia and more.

CBD offers natural relief from pain. Those who took CBD to lessen chronic pain, found surprising results. There’s a scientific reason why CBD is so effective in alleviating pain. Chronic inflammation is often neuropathic pain in disguise, especially if the pain lasts after the inflammation heals. CBD can reprogram the neuro pathways and alley the pain.

CBD lowers high insulin level in the blood. It has been found by numerous studies including one conducted by the American Journal of Medicine. The study revealed that marijuana consumption can cause fasting insulin level to go down by a whopping 16%.

In the year 2013, the British Journal of Clinical Pharmacology cited CBD’s effectiveness in improving cardiovascular health. Through clinical trials, they found CBD can reduce vascular hyperpermeability, which is known commonly as leaky gut.

CBD is very popular among cancer patients. There have been scientific studies as well as anecdotes describing the benefits of CBD in preventing the growth of malignant tumors. Unlike invasive cancer treatment procedures like chemotherapy, which negatively affect non-tumor cells, CBD, owing to its non-toxic nature doesn’t harm those cells.

CBD adoption

Research has been going on since the mid-2000s to understand CBD. The adoption rate, however, increased only lately. And that’s largely because celebrities endorsing CBD is a recent phenomenon. Also, there were not enough sources in the past that could educate us on the benefits of CBD. However, all these are changing now and that’s a good thing.

Concluding remarks

Perception is reality. Perception of CBD is changing and so is the reality around it. I personally won’t be surprised to see it becoming mainstream in the medical world. And you shouldn’t be either.

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